The Bavarians retained their league title in record time on Tuesday and their visitors may sense an opportunity to seize advantage of a post-celebration hangover
Hoffenheim will hope to take gatecrash Bayern Munich's Bundesliga party on Saturday.
Pep Guardiola's men completed their title defence on Tuesday with a 3-1 win over Hertha Berlin as goals from Toni Kroos, Mario Gotze and Franck Ribery saw them over the line in record time.
Bayern wrapped up a 24th league championship with seven games to spare and will now attempt to avoid defeat in the run-in to become the first side in Bundesliga history to enjoy an unbeaten campaign.
The Bavarians need 14 points to match the division's record points total, which they set last season, and will be strong favourites to add to their tally this weekend as they go in search of a 20th straight win.
Hoffenheim would appear to have little left to play for. Back-to-back wins - the latest coming against Hannover in midweek - have countered two previous losses and given them a lift, but their outside hopes of a top-six finish still look to have faded.
And if they are to register an unlikely victory against Guardiola's men they will likely need a superhuman defensive effort, having shipped 15 goals in their last six games - keeping just one clean sheet in the league this term.
Bayern, meanwhile, are one goal away from 80 in the top flight this season and are close to setting a new record for the fewest conceded in a Bundesliga campaign.
The current record, set by FCB, stands at 18, with Manuel Neuer and back-up Tom Starke - with a single appearance against Hannover in February - conceding just 13 this term.
Neuer is also five clean sheets away from matching last season's record of 21, again set by the champions.