The Werder Bremen goalkeeper has left the national team camp immediately because of illnesss in his family, leaving Joachim Low with only 18 players in his squad
The Werder Bremen shot-topper left the team on Saturday, the day after Joachim Low's men defeated Austria 2-1 courtesy of a Mario Gomez brace.
Wiese's departure has left Low with only 16 outfield players and two goalkeepers following a string of injury problems.
Midfielders Bastian Schweinsteiger, Sven Bender and Christian Trasch have all exited the squad with knocks alongside attackers Miroslav Klose and Marco Reus.
Wiese is Germany's third choice goalkeeper behind Bayern Munich's Manuel Neuer and Bayer Leverkusen's Rene Adler.
The 31-year-old keeper has made three international appearances, picking up his debut as a second-half substitute in a friendly versus England in 2008.