The Foxes currently sit top of the table after beating Manchester City courtesy of goals from Robert Huth and Riyad Mahrez, while the Gunners remain five points further back despite beating Bournemouth.
But Arsenal have already landed a heavy blow before they meet on the pitch, having lured Wrigglesworth – who had a hand in the signing of players such as Mahrez and N’Golo Kante – to north London.
The highly rated analyst, who will now take on the role of first team video scout at Emirates Stadium, confirmed the move on social media.
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"After three-and-a-half unbelievable seasons, working with amazing people, I am now starting a new chapter," he said.
"It was a very difficult decision, leaving Leicester, but I had to take an opportunity that doesn't come round often.
"I only wish the best for Leicester in the future and will always be eternally grateful to them for getting me to where I am."
Arsenal fans will be hoping Wrigglesworth can unearth some more gems like Player of the Year contender Mahrez following his switch, while there is speculation that he could soon be joined at the club by Leicester’s head of scouting Steve Walsh.