The Italians were sent packing from Europe's elite club competition after losing both legs by the same 2-0 scoreline.
Roma were unable to carry their fine form in Serie A of late into their last-16 affair with Real, spurning a number of good goal-scoring opportunities across both matches.
Florenzi, Edin Dzeko and Mohamed Salah were all guilty of missing chances in the second leg at the Santiago Bernabeu as strikes from Cristiano Ronaldo and James Rodriguez handed Real victory on Tuesday evening.
And Florenzi has pinpointed Roma's lack of cutting edge in the final third as the key to their downfall at the hands of the Spaniards.
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"We had many chances in the first leg and we had many chances today, but if you don't score you can't go through," Florenzi is quoted as saying by UEFA.com.
"Sometimes it doesn't depend on experience, you just have to be more precise.
"It's a pity, with some more efficiency it could have been another story. We played two good games, we played our football very well."
Roma's attentions now turn to a Serie A trip to Udinese on Sunday, when they will hope to extend a seven-match winning run in the league.