The African nation have inflicted defeat on Jurgen Klinsmann's side at the last two World Cups and will attempt to make it a hat-trick of victories on Monday night
Tim Howard has insisted the USA will not think about their previous failures against Ghana when they face the African nation on Monday night.
Ghana beat the USA in the group stage at the 2006 tournament, before emerging victorious again in the second round four years later.
The two sides have been paired yet again in Group G this time around, along with Portugal and Germany, but Howard is confident the previous meetings between the nations will have little impact.
"Not a word's been spoken (about the game)," the Everton goalkeeper said.
"We've said that all along. That was four years ago. It's ancient history, really, in the way football is looked at.
"This is a different team, with a different mind-set."
Howard did admit, however, that Ghana would pose similar threats to last time: "I think they are very similar (to 2010). They are strong individually.
"Obviously, we know how physical they are so we are going to try to match that. I've said it before, very rarely do we get outmatched physically but this is a team that has the possibility of doing that.
"We'll make sure that doesn't happen and then just be kind of clever with our positioning and making sure that they don't hit us in transition."
In the next round of Group G matches, the USA will face Portugal, while Ghana are set to meet Germany.