The Real Madrid youngster will not feature at this summer's World Cup, while his team-mate Alvaro Arbeloa also misses out
Spain coach Vicente del Bosque has announced his 30-man provisional squad for this summer's World Cup in Brazil, with Real Madrid's Alvaro Arbeloa and Isco as two of the most notable absentees.
Isco has struggled to find his best form in the second half of the season after initially impressing at Madrid, which has now cost him his place in Del Bosque's roster, while Arbeloa has lost his spot to Dani Carvajal.
Meanwhile, Iker Casillas has made the cut regardless of his limited amount of playing time at Madrid this season, while Thiago Alcantara and Fernando Llorente have both made it, too.
Other surprising callups include Alberto Moreno, Ander Iturraspe and Koke.
Del Bosque will announce his final squad on May 25.
Spain meet Netherlands, Chile and Australia in Group B at the World Cup.
SQUAD IN FULL:
Goalkeepers: Iker Casillas (Real Madrid), Pepe Reina (Napoli), David de Gea (Manchester United)
Defenders: Dani Carvajal, Sergio Ramos (Real Madrid), Juanfran (Atletico Madrid), Raul Albiol (Napoli), Javi Martinez (Bayern Munich), Alberto Moreno (Sevilla), Jordi Alba, Gerard Pique (Barcelona), Cesar Azpilicueta (Chelsea)
Midfielders: Andres Iniesta, Cesc Fabregas, Sergio Busquets, Xavi (Barcelona), Santi Cazorla (Arsenal), Juan Mata (Manchester United), David Silva (Manchester City), Thiago Alcantara (Bayern Munich), Ander Iturraspe (Athletic Bilbao), Koke (Atletico Madrid), Xabi Alonso (Real Madrid)
Attackers: Diego Costa, David Villa (Atletico Madrid), Alvaro Negredo, Jesus Navas (Manchester City), Fernando Torres (Chelsea), Fernando Llorente (Juventus), Pedro (Barcelona)