The Spain centre-back says he and his team-mates would be completely nonplussed by the Portuguese's potential return to the Santiago Bernabeu
The Blancos qualified for the last four with a 3-2 aggregate win over Borussia Dortmund and could now be paired with Chelsea, who overcame Paris Saint-Germain on away goals.
With Mourinho having left the Santiago Bernabeu in acrimonious circumstances last summer to return to Stamford Bridge, the Portuguese's return to the Spanish capital would be huge news, but Ramos insists that it would make no difference to the players.
"Getting Chelsea would neither work for or against us," the defender told reporters. "To win the Champions League, you have to beat the best teams and Chelsea deserve to be there."
Ramos' Madrid side were somewhat fortunate to avoid an embarrassing collapse at Signal Iduna Park on Tuesday, with Marco Reus' first-half double having left Blancos fans fearing the worst, but Madrid managed to prevent Dortmund from forcing extra-time - albeit with the aid of the woodwork.
"I have a lot of respect for the way Dortmund played," Ramos continued. "They have a great team and tonight they had the support of their fans too - they didn't reach the final last season for nothing.
"Dortmund are a great club with a team that demands respect. We showed them a lot of respect in spite of our first-leg victory and had various problems.
"We improved in the second half and enjoyed a bit more possession than before the break. Overall, I think we deserved to go through."