The Argentine coach has urged his men to give their all against Zenit and added that Hulk is not the Russian side's only threat
The Liga outfit sit top of Group G with 12 points from four games and have already secured their place in the last 16.
However, Simeone is demanding his side reach the high standards they have set this season.
"The main thing is that on the pitch we show the hunger to win and the desire to play classy football," Simeone said at a press conference.
"It does not matter if we have gone through or not, nor the way we've played before. What is important is the game itself, and not what is happening around it."
Simeone then went on to stress that Atleti cannot afford to focus solely on Hulk as Zenit have more to offer than the Brazil international.
"Hulk is not Zenit's only strong player. Our opponents have a strong attack made up of internationals. Zenit have strong, rapid transition from defence to attack, that could create problems for us."
Atletico recorded a 3-1 win at the Vicente Calderon in the reverse fixture.