The 24-year-old has warned that their 5-1 derby victory earlier in the season will count for little should they fail to attain a Europa League place
The Rojiblancos recorded a 5-1 thumping in the reverse fixture back in the autumn, but the 24-year-old has warned that bragging rights in Andalucia will count for nothing if they are unable to reach a Europa League qualifying spot come the end of the season.
"They are currently above us [seventh] and beyond our reach, but we will keep playing for our lives until the very end. If we win, it will be a much greater morale boost than the [2-1 win] against Athletic [Bilbao]," he told SFC Radio.
"Of course, it means nothing if we don't achieve our objectives. The 5-1 win is not enough because the most important thing is to be in Europe, not to say we won both games against Betis. We have to be clever and play without allowing any anxiety in the atmosphere to influence us."
Perotti, who returned to action against Athletic after three months out through injury, revealed he was blown away by the reception from the home support after he appeared as a second-half substitute on Monday.
"As soon as I left the bench, the reception was awesome," he added. "Although I know there are a lot of people who have affection for me, I did not expect something like this."
Sevilla sit in 10th place six points behind Betis.