The young defender is being plagued by physical problems and could miss the upcoming match versus the Turkish champions
The centre-back sustained a back injury on international duty with France, and will consequently miss Saturday's Liga match against Real Zaragoza.
It's uncertain as of yet how long Varane will be out of action, but Madrid fear that the 19-year-old could miss Wednesday's game at the Santiago Bernabeu, too.
Varane has developed into a key player at the Blancos in the past few months as he condemned Pepe to the bench in crucial games against Barcelona and Manchester United.
The youngster has made 25 appearances in all competitions for Madrid so far this season, scoring twice in the process.