Although every encounter between these two eternal rivals carries at least a modicum of significance, Saturday's game at the Santiago Bernabeu could be one of the most meaningless in recent memory.
With Madrid 16 points behind Barcelona in the league, Los Blancos will be fully focused instead on Tuesday's monstrous Mancunian meeting at Old Trafford which will decide their Champions League fate.
Having already beaten Barcelona once this week in the Copa del Rey semi final, there is little wonder that here in Spain, the press are referring to Saturday's game as a "de-caffinated Clasico".
This should not deter punters from investing in the match though, because despite it likely being a more sedate affair than previous meetings, there is still surely profit to be made.
Bet365 price Barcelona as the favourites at 11/8 (2.37) while Real Madrid, who have not lost a league game at the Bernabeu since December 2011 are offered at 15/8 (2.37). The draw can be backed at 5/2 (3.50).
The debates raging on the radio phone-ins across the Spanish capital this week have centred on whether Jose Mourinho should field a weakened side for the visit of Barca, given his side's European commitments just three days later.
Some of the more left-field suggestions have included fielding Real Madrid's B team and resting every first choice player, and although Mourinho is unlikely to do this, we could well see some squad players getting a game.
This being Madrid of course squad players mean the likes of Kaka, Luka Modric and Michael Essien footballers of undoubted quality so while it may seem "weakened", whichever XI takes to the field for the hosts should be able to compete adequately.
Nevertheless, expect this Clasico to be a little less frenetic than others, and the price of 27/20 (2.35) for under 2.5 goals looks tempting.
In their meeting on Tuesday night Barca lacked incisiveness in front of goal, while Madrid are unlikely to start with the same side that was so devastating on the counter-attack.
This bet paid out the last time the two teams met at the Bernabeu a month ago, and has also paid out in three of Madrid's last four home games as well as three of Barca's previous four away matches.
For a value bet, back a goal-less first half which is offered at 5/2 (3.50).
|Under 2.5 goals at 27/20 (2.35) with Bet365
||Under 0.5 first half goals at 5/2 (3.50) with Bet365|
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Phil Kitromilides is a sports anchor working on TV in Madrid. You can also follow Phil on Twitter.