The home side name a much-changed line-up for this evening's match at Camp Nou, with their two experienced Spain internationals among those rested ahead of this week's Clasicos
The due are named on the bench for the Catalan giants, as well as Jordi Alba.
Martin Montoya starts at left-back in place of Alba, while Alex Song and Thiago form a midfield three alongside Andres Iniesta in the absence of Xavi and Busquets.
Up front Lionel Messi is flanked by Alexis Sanchez and David Villa, with the latter having recoverd from kidney stones to be involved this evening.
Carlos Puyol and Cesc Fabregas do not make the matchday squad.
Sevilla also rest players tonight, as Unai Emery keeps one eye on their Copa del Rey semi-final second leg against Atletico Madrid.
Alvaro Negredo is replaced by Babo in attack, while Jose Antonio Reyes makes way for Manu del Moral.
Emir Spahic is suspended for the Andalusian side and Cicinho, Diego Perotti and Piotr Trochowski remain sidelined through injury.
Barcelona (4-3-3): Valdes; Alves, Pique, Mascherano, Montoya; Iniesta, Song, Thiago; Alexis, Messi, Villa
Subs: Pinto, Bartra, Alba, Busquets, Xavi, Pedro, Tello
Sevilla (4-2-3-1): Beto; Coke, Botia, Fazio, Navarro; Medel, Maduro; Navas, Rakitic, Manu; Baba
Subs: To follow