The Colombian forward has been in fine form this season, scoring 13 goals in nine games in all competitions to help Diego Simeone's side to joint-top spot in the Liga table.
And the Frenchman is aware of the threat that the former Porto striker will pose, but is also wary of the likes of Arda Turan and Adrian.
"The most important thing is to be very focussed and do well together and go fast on the break and take advantage of opportunities that we have, but we must also be attentive to Arda and Adrian, they are all very dangerous," he told AS.
Joao Pereira also stressed that it would be wrong only to target Falcao on Saturday, and urged his side to band together and put in a team performance.
"He's a great scorer, but to beat Atletico and, we have to play as a team and not think only Radamel," Pereira added.