The Spain internationals come in for the Blaugrana, as Pep Guardiola rings the changes against a visiting side looking for Champions League qualification
Dani Alves comes in at right-back, replacing youngster Martin Montoya. Meanwhile, in midfield, Cesc Fabregas and Andres Iniesta replace Thiago Alcantara and Sergio Busquets respectively.
Up front, the Blaugrana make just the one change as Isaac Cuenca comes in for the injured Alexis Sanchez.
For Malaga, they also make four changes from the side that beat Valencia 1-0 on Sunday, with Sergio Sanchez, Duda, Diego Buonanotte and Francisco Portillo replacing Weligton, Isco, Joaquin and Enzo Maresca.
If Barca lose, then Real Madrid will clinch the Primera Division title ahead of their trip to face Athletic Bilbao later tonight.
Barcelona (4-3-3): Pinto; Alves, Mascherano, Puyol, Adriano; Keita, Fabregas, Iniesta; Pedro, Messi, Cuenca
Malaga (4-4-1-1): Kameni; Jesus Gamez, Demichelis, S. Sanchez, Eliseu; Portillo, Camacho, Cazorla, Duda; Buonanotte; Rondon