The Catalan side travel to the capital as they look to get back to winning ways after damaging results against Real Madrid and Chelsea
20-year-old defender Martin Montoya has been given the nod to start at right-back in what will be his fourth appearance in the Primera Division this season. Jose Pinto is given the nod in goal, with Victor Valdes being named a substitute.
The midfield trio of the visitors is made up of Seydou Keita, Thiago, and Sergio Busquets with Andres Iniesta and Cesc Fabregas having to settle for a place on the bench. Xavi misses the match after picking up a calf problem.
Jose Ramon Sandoval has named a positive line-up for the visit of the Catalan side, with both Diego Costa and Raul Tamudo starting up front in a two-man strikeforce.
Mikel Labaka and Jose Manuel Casado are suspended for the match and their place in the Rayo defence has been taken by Alejandro Arribas and Jorge Pulido.
Rayo Vallecano (4-4-2): Cobeño; Tito, Arribas, Pulido, Rober; Lass Movilla, Trashorras, Michu; Tamudo, Diego Costa
Barcelona (4-3-3): Pinto; Montoya, Puyol, Mascherano, Adriano; Busquets, Keita, Thiago; Messi, Alexis Sánchez, Pedro
Subs: Valdés, Alves, Iniesta, Bartra, Tello, Cesc, Afellay