The Santiago Bernabeu outfit head into the match against their Catalan rivals four points clear at the top of the Primera Division table, meaning that a draw will be enough to see Los Blancos get within touching distance of the league crown.
Former Madrid coach Bernd Schuster said on Thursday that Jose Mourinho's side will play for a draw against Barca, but Karanka has pointed out that the team has gone out on attack against the Catalans in recent matches.
"We will not go there to speculate," Karanka told reporters at a press conference. "This game will resemble the last matches we had there, in which we scored goals and secured draws.
"In Saturday's game, we will need to have that same attitude.
"These are three important points, but after this match, we will still have to play four more games, whether we win, lose, or draw against Barca."
Karanka then stressed that the players are not thinking about the upcoming Champions League clash against Bayern Munich and played down criticism levied at Fabio Coentrao for his display against the Bundesliga club on Tuesday.
"What we are focused on right now is Saturday's game," Karanka noted. "We are not thinking any further.
"Coentrao? What we asked him to do was to keep [Arjen] Robben from outrunning him, scoring, and crossing, and he did his job well.
"Sometimes it is easy to criticise someone."
Questioned if the players are tired from their midweek contest, Karanka said: "There have been suspensions, injuries and squad rotations. For a match like Saturday's, there is no such thing as fatigue.
"I hope that the match will be normal and that the fans will be satisfied with what they see."
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