The prolific attacker previously featured in Nicosia when Portugal took on Cyprus in Euro 2012 qualifying and was provoked by the home side's supporters
The 27-year-old previously played at APOEL's home ground on September 2, 2011 when he guided Portugal to a 4-0 win over Cyprus in a Euro 2012 qualifier, and Ronaldo received a rude welcome from the home fans.
The attacker was continually taunted by the Cypriot faithful, who chanted 'Messi, Messi' in an attempt to upset the former Manchester United star.
Ronaldo struggled to contain his frustration after the game, and stressed that the fans' behaviour was 'abnormal'.
A little over six months later, the attacker will again set foot in the GSP Stadium and could receive similar treatment on Tuesday night.
For the next 10 weeks, Goal.com will be publishing exclusive extracts from Luca Caioli's new book, Ronaldo: The Obsession for Perfection. Check out the first extract, published on Friday, which looks at the Portuguese forward's humble beginnings in Madeira. Don't miss it!