The hosts go into the game eighth in the table, 14 points behind their second-placed rivals, who to their La Liga and Champions League titles.
Pochettino admits that trying to come up with a game plan to bring down Barca is a daunting task but he disagrees with Osasuna counterpart Jose Luis Mendilibar’s assertion that Pep Guardiola’s side are virtually unbeatable.
"You cannot win a game with this mindset,” the Espanyol coach is quoted as saying by Marca. "It is impossible."
“For our part, we will go after them but with respect and modesty."
Pochettino acknowledges that it is one thing talking the talking and quite another actually walking the walk.
"Everybody has a lot of theories or formulas for beating Barca, but the truth to bring these theories into practice is quite difficult," he pointed out.
Espanyol go into the game on the back of an embarrassing 2-1 defeat by Segunda B outfit Cordoba in the Copa del Rey.
Starting in November and continuing through January, Goal.com is publishing exclusive extracts from Graham Hunter's highly-anticipated new book, 'Barca: The Making of the Greatest Team in the World'. Last Friday's extract took a closer look at the most influential figure in the club's history: Johan Cruyff: Don't miss it!