Pep Guardiola will line-up with a three-man defence, while Dani Alves and Seydou Keita drop out of the side which will face Levante at Camp Nou
Dani Alves drops to the bench, as does Seydou Keita, while Cesc Fabregas and Sergio Busquets come into the starting line-up with Pep Guardiola opting for a tactical reshuffle.
David Villa celebrates his 30th birthday on the substitutes' bench with Isaac Cuenca brought into the team to face Liga's surprise team of the season so far.
Barcelona will be hoping for all three points as they look to keep the pressure on leaders Real Madrid ahead of next week's highly anticipated Clasico at the Santiago Bernabeu.
Barcelona (3-4-3): Valdes, Puyol, Mascherano, Abidal; Xavi, Busquets, Fabregas, Iniesta; Sanchez, Messi, Cuenca
Levante (4-5-1): Munua; Javi Venta, Ballesteros, Del Horno, Juanfran; Pedro lopez, Iborra, Farinos, Xavi Torres, Valdo; Kone