The Liga champions have announced a three-man defence against Levante on Saturday with Carles Puyol coming in for the suspended Gerard Pique.
Dani Alves drops to the bench, as does Seydou Keita, while Cesc Fabregas and Sergio Busquets come into the starting line-up with Pep Guardiola opting for a tactical reshuffle.
David Villa celebrates his 30th birthday on the substitutes' bench with Isaac Cuenca brought into the team to face Liga's surprise team of the season so far.
Barcelona will be hoping for all three points as they look to keep the pressure on leaders Real Madrid ahead of next week's highly anticipated Clasico at the Santiago Bernabeu.
Barcelona (3-4-3): Valdes, Puyol, Mascherano, Abidal; Xavi, Busquets, Fabregas, Iniesta; Sanchez, Messi, Cuenca
Levante (4-5-1): Munua; Javi Venta, Ballesteros, Del Horno, Juanfran; Pedro lopez, Iborra, Farinos, Xavi Torres, Valdo; Kone