The Real Madrid captain will be rested for the Scotland clash on Tuesday, meaning he will make history in La Roja's next match, at Wembley in a friendly in November
Casillas made his international debut aged 19 in 2000, and quickly cemented his place in the national side, captaining his country to victory in both Euro 2008 and the 2010 World Cup.
"Personally, it is special. I look back and see that I have been in the team for 11 years, and that is very rewarding. Every coach has backed me, and I am grateful," said Casillas on reaching the milestone.
His record at international level is made all the more impressive by the fact that Spain have conceded just 73 goals in his 125 games between the sticks, compared to Zubizarreta's 99.
The keeper now looks certain to equal the record against England at Wembley in November.