Angel Di Maria, Ricardo Carvalho, Gonzalo Higuain and Antonio Adan come into the starting line-up for Real Madrid against Getafe
Kaka, Karim Benzema and Sergio Ramos are the three players to make way with Mourinho taking advantage of the wealth of talent he has at his disposal.
Antonio Adan makes a rare start in goal for Madrid with Iker Casillas rested for the league encounter.
The Whites need a victory against Getafe to stand any chance of lifting the La Liga title with Barcelona playing Levante on Wednesday night.
The official lines up have been confirmed and are as follows:
Real Madrid (4-2-3-1): Adan; Arbeloa, Pepe, Carvalho, Marcelo; Xavi Alonso, Diarra; Di Maria, Ozil, Ronaldo; Higuain
Subs: Mejias, Albiol, Garay, Granero, Pedro Leon, Adebayor, Benzema
Getafe (4-2-3-1): Ustari; Torres, Diaz, Mario, Mane; Casquero, Boateng; Sardinero, Parejo, Arizemendi; Colunga
Subs: Miku, Mosquera, Kas, Borja, Pintos, Codina