Visiting coach Jose Mourinho has decided to drop Gonzalo Higuain to the bench and replace the Argentine with Karim Benzema, who had a watching brief in the CL semi-final
Elsewhere, Kaka retains his place in the attacking midfield triumvirate and there are two changes in defence. The suspended duo of Ricardo Carvalho and Angel Di Maria make way for Pepe and Mesut Ozil respectively with Sergio Ramos replacing Raul Albiol in central defence.
With Croatian midfielder Ivan Rakitic out for the rest of the season, Didier Zokora partners Guy Medel in the heart of Sevilla's midfield and Frederic Kanoute continues upfront alongside Alvaro Negredo.
Sevilla starting XI: Javi Varas; Sergio Sanchez, Fazio, Escude, Fernando Navarro; Capel, Medel, Zokora, Romaric; Kanoute, Negredo
Substitutes: Palop, Renato, Dabo, Kone, Perotti, Alfaro, Dragutinovic
Real Madrid starting XI: Casillas; Arbeloa, Sergio Ramos, Pepe, Marcelo; Lass, Xabi Alonso; Ozil, Kaka, Cristiano Ronaldo; Benzema
Substitutes: Dudek, Granero, Adebayor, Garay, Albiol, Canales, Higuain