The Manchester United youngster is to start Tuesday's friendly after becoming the Under-21s' highest goalscorer of all time, with David Meyler also getting a first cap
Sunderland midfielder David Meyler will also be making his international bow as Boys in Green boss Giovanni Trapattoni tries some new faces following Friday's 2-1 win over Kazakhstan in World Cup 2014 qualifying.
Striker Kevin Doyle, who scored a late winner in that opening fixture of the qualifying campaign but had been disappointed with the team's performance as a whole, will captain the side at Craven Cottage.
Ireland Under-21s manager Noel King praised Trapattoni's decision to call up Brady on Saturday, the Red Devils youngster having recently become the youth side's all-time top goalscorer.
Republic of Ireland starting XI: Forde; Coleman, McShane, Wilson, Kelly; Meyler, McCarthy, Brady; Doyle, Long, Keogh.
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