Barcelona have confirmed that the Mexico international will bring an end to his 12-year stay at Camp Nou to join their Liga rivals
The 24-year-old midfielder has failed to make the breakthrough in the Barca first team and is now is to end a 12-year stay Camp Nou.
And now Dos Santos will join his older brother Giovani at el Madrigon.
"Barcelona and Villarreal CF have agreed to terms for the player Jonathan dos Santos," read a statement on the Barcelona club website.
"The transfer fee, which is a combination of a fixed sum and variables, could reach €2 million, and FC Barcelona reserve the right to be involved in the possible future sale of the player."
The Mexico international managed just 9 appearances for the first team since his promotion from Barcelona B, with a cruciate ligament injury suffered during training in October 2013 having curtailed his development at the club.
Villarreal confirmed on their official website the player has agreed a five-year deal and will complete his transfer after passing a medical.
Dos Santos is scheduled be officially presented as a Villarreal player at a press conference on Thursday.