The current Serie A champions go into the new campaign seeking a new striker and have been strongly linked with a move for the Dutchman throughout the summer
The 28-year-old enjoyed an exceptional season last term, striking 30 Premier League goals on his way to winning the PFA Player of the Year award.
However, he has since announced over the summer that he does not plan to extend his deal to stay at the club beyond the end of this season.
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Alongside Manchester City, the Bianconeri were thought to be the front-runners for the Dutchman's signature.
However, Marotta believes too much has been made of their interest in the player, citing Arsenal's reluctance to sell as a major stumbling block.
"A top player is not only judged by how much he costs," he told Sky Sport Italia.
"It can also mean a player who costs less but on the pitch shows an absolute value.
"Van Persie is a great player but Arsenal do not intend to lose him.
"And you cannot indulge in a player if the owners don't want [to sell]."Talk of our real interest in him seems excessive to me."
Antonio Conte's club are thought to be in the market for a striker this summer as they look to make an impact on their return to the Champions League next season.