The Frenchman has piled the pressure on the Partenopei ahead of Roma's visit to the San Paolo on Sunday and is hoping his side can avenge their Coppa Italia exit
The Giallorossi are six-points above Rafael Benitez's men with a game a hand heading into the second versus third clash at the Stadio San Paolo.
And Garcia believes the Partenopei can ill afford to slip up when the two sides lock horns in a mouth-watering encounter.
"There are another 11 games after this for them, 12 for us, and we have a six-point advantage with a game in hand," the former Lille boss told reporters on Saturday.
"The pressure is on Napoli, as if they lose tomorrow then it's practically all over. If we lose, we'll still be in second place with a buffer. We are strong, so are they."
The game marks the fourth time this season the two have faced one another, following Napoli's 5-3 aggregate victory in the Coppa Italia semi-final stage - after Roma had won the first leg 3-2 - and Garcia wants Roma to win this time.
"I hope to see the same kind of spectacle that we had in the Coppa Italia semi-final first leg," he added. "So far this season we have played Napoli three times, winning twice.
"They have the second most prolific attack in Serie A, we have the third. Anything can happen and we must show, as we did after losing to Juventus in Serie A and beating them in the Coppa Italia, that we can win anyway.
"I hope that the best team wins, I hope to see a great game and we need everyone to be at 100 per cent for that to happen.
"The real problem in the Coppa against Napoli was distraction on set plays, so tomorrow we must be ready to make the most of those situations.
"Of course a draw would be acceptable, but if you play for a draw then you risk defeat. We must always play looking for the victory."