The Brazilian joined Inter from Lazio in January having hit nine goals in Rome derbies during his three-and-a-half year spell with the Biancocelesti.
And the 28-year-old insists he would still love to beat Rudi Garcia's side at his old home, the Stadio Olimpico, despite considering himself to be on good terms with Giallorossi fans.
"It can’t help but be a special opponent," he told La Gazzetta dello Sport. "I have always had a peaceful rapport with Roma fans. They’d ask me for a picture and then say they were Romanisti.
"The way to face Roma is to play like they do, to keep the tempo up, press them high up the field without the ball and be sure not to make mistakes coming out of your own half.
"Every mistake can be a counterattack and a very costly one too."
Hernanes graced the second Rome derby of last season with a superb strike in a 1-1 draw and the Brazil international labelled the effort one of the best of his life.
"The most important goal I scored against Roma was also perhaps the greatest of my career," he added. "I combined with Senad Lulic, feigned a shot with my right foot and then took it on to my left for a shot into the top corner."
Inter sit fifth in Serie A, 17 points behind Roma and 11 behind third-place Napoli who occupy the final Champions League place.