The Argentina international believes the meeting with the Serie A leaders is too early in the season to prove decisive and insists he will not think about the Scudetto race yet
Rafael Benitez's men take on leaders Roma next Friday, with both sides unbeaten in the Italian top flight to date this season.
However, champions Juventus are also yet to lose a game in the league, and Higuain believes there are plenty of twists and turns to come during what promises to be a lengthy battle for the Scudetto in 2013-14.
"It is too early to talk about it. For us, we will not think about it until 72 hours beforehand," Higuain said of the game at the Stadio Olimpico.
"It is indisputable that it will be an important game, capable of sending an additional signal, but nothing more, it is no final.
"The season is very long, there is no eventuality that will change my mind, whatever happens."
The Argentina international went on to stress that talk of whether champions Juventus remain the strongest side is best left for the midway point in the season, insisting his primary focus is to improve his own game at Stadio San Paolo.
"Are Juventus stronger in the title race? We cannot even say we are at the end of the first half of the season and in a title race complicated things can happen," he continued.
"We need to at least wait until the end of the first half of fixtures to sense the true forces and then even that may not be enough.
"But anyway, I am generally not accustomed to the interest of others, I am thinking about my team, to improve, to grow through training.
"I do not have a tendency to mind other people’s business, but it is indisputable that the champions of Italy do not lack class players."