The San Paolo showdown had been set to go ahead on the first Saturday after the international break but it has been moved because of a clash with a planned protest in the CityNapoli's eagerly-awaited meeting with Serie A leaders Roma has been brought forward 24 hours, meaning it will now take place on October 18 at 20:45CET.
The game at the San Paolo had been scheduled to go ahead on the first Saturday after the current international break but that would have seen the top-of-the-table encounter clash with a planned protest in Naples.
Given the strain that would have placed upon the city's police force, Lega Calcio has now decided to move the match to the Friday night.
"Roma-Napoli is clearly a game that must be played and it makes no sense that we pit ourselves against one another, but this solution causes more [logistical] problems for us than the Giallorossi," the Napoli supremo told reporters on Monday.
"The most important thing, however, is that a solution has been found that gives due prominence to the game.
"Right now we are talking about a match that can be considered as the game of games."
Roma have won all seven of their Serie A fixtures so far this season, while second-placed Napoli have dropped just two points.