The veteran defender has warned that a tough test awaits against the Rosanero, and feels his side must take things one game at a time
The Rossoneri beat Genoa 1-0 at the weekend to climb to 11th spot in the table, whereas the Sicilians were held to a scoreless draw by Siena and have to settle for 18th position in the standings.
Nevertheless, Yepes has warned that Palermo will not be pushovers as he feels they could trouble Milan at the Stadio Renzo Barbera.
"It will be a difficult match against Palermo. They have changed coach and changed the way they play, plus it's a tough ground to play at," Yepes told reporters.
"The win over Genoa is dedicated to everyone at Milan from the staff to the fans. Now we have to take things one game at a time and not think too much about what this weekend's victory could do for us."
Tuesday's encounter is scheduled to kick off at 20:45CET.