Juventus will be without Gianluigi Buffon and Mirko Vucinic for Saturday's crucial match with Napoli.
Buffon has failed to recover from a thigh injury sustained during Italy's World Cup qualifying win over Armenia, while Montenegro attacker Vucinic is suffering from a bout of flu.
There is some good news for the Bianconeri, however, with midfielder Claudio Marchisio set to play after recovering from a shoulder problem, while Leonardo Bonucci returns from suspension for the top-of-the-table clash.
Meanwhile, the agent of veteran keeper Buffon has confirmed that there is still no progress to report on the 34-year-old's contract extension at Juventus Stadium.
"For the moment there is no need to talk about it. These are delicate things, however, at the right time [we] will come out of it all," Silvano Martina told tuttojuve.com.
Martina also revealed he is expecting a tight game on Saturday, but insists it will not prove to be decisive in the title race.
"At this time Juve is the defending champion and is proving to be the strongest in Italy. Napoli, on the other hand, has grown a lot and is the main antagonist in the Scudetto," he continued.
"I expect a very good game; however, as the race for the championship, it comes much too early to be decisive."
Martina also insists that the international commitments of players has an impact on all the top clubs, and so he does not envisage it causing a problem for the clash this weekend.
"Now for all clubs it is so," he added. "Having players around Europe or returning from South America affects us all, not only one of the two clubs, so I do not think it will particularly affect the performance of game. "