The Italian coach feels that the Manchester City striker has finally turned a corner in his Azzurri career and is seeking consistency from his player in upcoming matches
The explosive striker was on target as Italy extended their lead at the top of World Cup qualifying Group B by beating Denmark 3-1.
And his national boss is confident that the Manchester City player can be a huge weapon for Italy and urged the 22-year-old to keep up the good work.
"He has understood what he has to do for Italy," Prandelli told reporters after Italy's triumph over Morten Olsen's side.
"I say that from now on the Balotelli in an Azzurri jersey has to be the one we saw at San Siro against the Danes."
Balotelli has often been criticised for his lack of commitment or temperament, but Prandelli insists that he is not a liability.
"When I talk about Balotelli, I do not like the suggestion he is a gamble, but the moment has certainly come for him to take his share of responsibility in an Italy shirt," he continued.
"I want a national team that is always targeting improvement, even if I’d like to have more time to try out some young players."