The Rossoblu chief, who owns half of the player's rights, has stated that discussions over a transfer have broken down and feels the talented striker is being selfish
The talented forward is co-owned by Siena and the Rossoblu, and has been linked with a switch to the Italian capital.
However, the attacker is believed to have turned down a move to the Giallorossi after wage disputes, which has infuriated Preziosi.
“Inter, Milan or Juve? Destro was promised to Roma and I keep my word. Mattia has the right to turn down Roma, but in that case he will stay with Siena on the €400,000 contract he has and not the millions Roma wanted to give him,” Preziosi told Sky Sport Italia.
“In my 22 years in football, the Destro affair is the silliest thing that has ever happened to me.
“Everyone is trying to look after their own interests, but that then creates problems. We are talking far too much about a lad who so far has scored only 10 Serie A goals, so Destro still needs to prove himself.
“Of course when someone sees his name in the papers every day then he tends to demand scandalous sums for a player his age. Competition raises the price-tag, but Destro doesn’t deserve this tug of war."
“The negotiations have hit the rocks and it looks very bleak. It is a scandalous situation and if he doesn’t seal the deal [to Roma] then he will remain at Siena.
“Then there are clubs who play on wages and lads who prefer to follow an extra €200,000 rather than seek a team that suits them.
“I have to say these negotiations shocked me. I am nauseated and have never seen anything like it.
“There are players who think they have already arrived and create complications, while their agents believe they’ve found the goose that lays the golden eggs.
“I do not need to cash in on half of Destro's economic rights. If by the end of Saturday the matter has not been resolved, then I give my word he will remain at Siena.