The Dutch midfielder misses the final game of the season with a slight muscle injury as both sides look to snatch third-spot away from Udinese with a last-gasp win
There had been suggestions that the Germany international would return to the starting line-up for Edy Reja's side after a brief substitute appearance in the win over Atalanta last week, but he does not make the squad. Libor Kozak therefore leads the line while Giuseppe Biava and Albano Bizzarri fill in for the suspended Federico Marchetti and Andre Dias.
With Hernanes and Matuzalem both sidelined with injury for the club from Rome, Cristian Ledesma is awarded a starting berth in midfield alonside Lorik Cana.
Inter need to win and other results to go their way if they are to sneak a spot in next season's Champions League but they will have to do so without midfield maestro Wesley Sneijder. He is replaces in midfield by Andrea Poli while Luca Castellazzi occupies the position of goalkeeper with Julio Cesar absent due to suspension.
Lazio (4-2-3-1): Bizzarri; Konko, Diakite, Biava, Sacloni; Cana, Ledesma; Candreva, Mauri, Lulic; Kozak.
Subs: Berardi, Garrido, Gonzalez, Makinwa, Zampa, Rozzi, Mauri.
Inter (4-5-1): Castellazzi; Maicon, Lucio, Samuel, Nagatomo; Zanetti, Cambiasso, Guarin, Poli, Alvarez; Milito.
Subs: Orlandoni, Cordoba, Ranocchia, Juan, Faraoni, Pazzini, Longo.