The Argentine picked up an injury against Fiorentina and missed three matches, while the Brazilian steps up in place of Antonio Cassano, but there's no Thiago Silva
The Argentine has missed three matches after exiting with an injury at half-time in the recent trip to Fiorentina, but starts this evening's fixture having made a full recovery. Ricky Alvarez gets the nod ahead of Mauro Zarate, and is likely to start just behind Diego Milito.
Neighbours Milan make a change up front, recalling Robinho in place of Antonio Cassano, while Daniele Bonera comes in at left-back for the injured Luca Antonini. Thiago Silva remains unavailable six weeks after injuring his hamstring against Roma.
Milan need a victory tonight as they enter the match a point behind Juventus in the Scudetto race, while a victory for Inter will keep them in with a chance of earning a Champions League spot.
The derby kicks off at 20.45CET.
Inter (4-3-2-1): Julio Cesar; Maicon, Lucio, Samuel, Nagatomo; Guarin, Cambiasso, Zanetti; Sneijder, Alvarez; Milito.
Subs: Castellazzi, Cordoba, Pazzini, Palombo, Obi, Ranocchia, Zarate
Milan (4-3-1-2): Abbiati; Abate, Nesta, Yepes, Bonera; Nocerino, Van Bommel, Muntari; Boateng; Ibrahimovic, Robinho.
Subs: Amelia, Mexes, Gattuso, Aquilani, Maxi Lopez, De Sciglio, Cassano