The Italy international has slipped down the pecking order in recent weeks but he gets his chance to shine at the Dino Manuzzi because of Fabio Quagliarella's suspension
The former Cagliari forward was an unused substitute in Sunday's 4-0 rout of Roma but he returns to the Bianconeri attack in place of Fabio Quagliarella, who misses the trip to the Dino Manuzzi due to suspension.
Matri's inclusion is one of just two changes to the side which hammered the Giallorossi in Turin, with coach Antonio Conte also opting to replace Stephan Lichtsteiner on the right-hand side of Juve's five-man midfield with Martin Caceres.
As for Cesena, Steve Von Bergen is suspended, resulting in a start for Guillermo Rodriguez at the back, while Marco Parolo slots back into the midfield after coming on as a substitute in the 2-2 draw with Palermo.
Jorge Martinez, Martinho and Daniel Pudil are all sidelined through injury as relegation-threatened Cesena seek to keep their head above water.
Juventus (3-5-2): Buffon; Barzagli, Bonucci, Chiellini; Caceres, Vidal, Pirlo, Marchisio, De Ceglie; Matri, Vucinic.
Subs: Storari, Lichtsteiner, Padoin, Marrone, Giaccherini, Borriello, Del Piero.
Cesena (4-3-1-2): Antonioli; Ceccarelli, Moras, Rodriguez, Comotto; Guana, Colucci, Parolo; Santana, Malonga, Rennella.
Subs: Ravaglia, Lauro, Benalouane, Arrigoni, Del Nero, Lolli, Filippi.