The Dutchman returns to the midfield ahead of a much-changed back four as the Rossoneri look to go back to the top of the Serie A table
Van Bommel replaces Gennaro Gattuso in midfield, while three changes at the back see Ignazio Abate, Daniele Bonera and Luca Antonini back in the side at the expense of Mattia De Sciglio, Mario Yepes and Gianluca Zambrotta.
Thiago Silva, Kevin-Prince Boateng and Massimo Ambrosini are all thought to be a week away from full fitness and remain sidelined, but the Rossoneri's injury crisis has eased somewhat in the fortnight since their last fixture.
Bologna will be spearheaded as ever by Marco Di Vaio with Alessandro Diamanti and Gaston Ramirez in close support as they look to pick up a victory which would all be assure them Serie A football again next term.
For the home side, a victory would send them top of the table ahead of Juventus' clash with Roma this evening.
Milan (4-3-1-2): Abbiati; Abate, Nesta, Bonera, Antonini; Nocerino, Van Bommel, Muntari; Seedorf; Ibrahimovic, Robinho.
Bologna (3-4-2-1): Agliardi; Raggi, Portanova, Cherubin; Garics, Perez, Mudingayi, Morleo; Ramirez, Diamanti; Di Vaio.