The seven-time European Cup winners are considered massive underdogs ahead of their clash with the Blaugrana, but the Rossoneri left-back is not afraid of Pep Guardiola's side
The Rossoneri welcome the Blaugrana to San Siro on Wednesday and few pundits are giving the Italian title-holders much chance of upsetting the reigning world, European and Spanish champions.
However, Mesbah believes that coach Massimiliano Allegri will do a fine job of shielding his squad from the negativity and pessimism of the press.
"The boss will do everything to motivate the team ahead of the Barcelona game and we shouldn’t be afraid of them, because we’re Milan," the versatile left-back told his club's official website.
Mesbah's defensive colleague, Daniele Bonera, is also talking up Milan's hopes of progressing to the last four, believing this current squad to be of a similar strength to the one which won the Champions League five years ago.
"All the Milan sides I’ve played have been different," the versatile centre-half mused. "In the first year I won the Champions League and this current squad is close to that."
Milan's meeting with Barca at the Giuseppe Meazza kicks off at 20:45CET.