The veteran attacker missed his side's previous Serie A encounter due to injury, but is expected to make his comeback in Saturday's clash against the Rossoneri
The 35-year-old forward picked up a thigh problem ahead of his side's 1-0 league win over Genoa on Monday, and was consequently forced to sit out the game.
Nevertheless, Totti is rapidly nearing full match fitness again, and will reportedly return to the starting XI for Saturday's meeting with Milan.
Roma were beaten 3-2 at the Stadio Olimpico earlier this season and will be looking to avoid a double when both sides meet again at San Siro this Saturday at 18.00CET.
The Giallorossi currently sit sixth in the Serie A table with 44 points from 28 games, trailing leaders Milan by 16 points and four adrift of third place, currently occupied by Lazio.