The striker came on as a substitute to net the equaliser against AC Milan last week, and starts alongside Emanuele Giaccherini and Mirko Vucinic against the Flying Donkeys
With suspensions ruling out Simone Pepe and Arturo Vidal, coach Antonio Conte has switched formation to the 4-3-3 cum 4-1-4-1 set-up which he used for much of the first half of the campaign, but it is Stephan Lichtsteiner, rather than Caceres, who fills the right-back slot.
Matri is joined up front by Emanuele Giaccherini on the right and Mirko Vucinic to his left.
Chievo boss Domenico Di Carlo has chosen to start with Alberto Paloschi up front on his own in the absence of club captain Sergio Pellissier, meaning Davide Moscardelli has to settle for a place on the bench.
A victory for unbeaten Juve would take them back to within a point of leaders AC Milan, who won the first of Saturday's fixture 4-0 away to Palermo.
Juventus (4-3-3): Buffon; Lichtsteiner, Barzagli, Chiellini, De Ceglie; Padoin, Pirlo, Marchisio; Giaccherini, Matri, Vucinic
Subs: Storari, Bonucci, Caceres, Del Piero, Marrone, Borriello, Qugaliarella
Chievo (4-3-2-1): Sorrentino; Sardo, Andreolli, Acerbi, Drame; Bradley, Rigoni, Luciano; Thereau, Sammarco; Paloschi
Subs: Puggioni, Dainelli, Frey, Cesar, Cruzado, Hetemaj, Moscardelli