The pair only made the bench for last weekend's dismal defeat at home to Novara but, with Diego Milito having been ruled out through injury, Pazzini will lead the line against the Rossoblu, while Forlan will play alongside Wesley Sneijder and Marco Faraoni in a three-pronged attacking unit just behind the former Sampdoria striker.
Argentine duo Javier Zanetti and Esteban Cambiasso have been charged with protecting a back four which has been buoyed by the return from suspension of right-back Maicon and the availability of goalkeeper Julio Cesar, who had been a minor doubt for the game.
However, Walter Samuel again misses out, meaning Andrea Ranocchia will line up alongside Lucio at the heart of the Nerazzurri defence.
As for Bologna, Nico Pulzetti misses out with a thigh problem but Panagiotis Kone has recovered from a muscle strain and has been included among the substitutes.
Inter (4-2-3-1): Julio Cesar; Maicon, Lucio, Ranocchia, Nagatomo; Zanetti, Cambiasso; Faraoni, Sneijder, Forlan; Pazzini.
Subs: Castellazzi, Chivu, Poli, Palombo, Obi, Zarate, Castaignos.
Bologna (3-4-2-1): Gillet; Raggi, Portanova, Antonsson; Garics, Perez, Mudingayi, Morleo; Ramirez, Diamanti; Di Vaio.
Subs: Agliardi, Taider, Pulzetti, Cherubin, Kone, Rubin, Acquafresca.
How do you stay up to date with football when on the move? With http://m.goal.com – your best source for mobile coverage of the beautiful game.