The Dutchman has not been risked by Claudio Ranieri with just eight days to go until the Milan derby, with the regular strike pair heading a 4-4-2 against Franco Colomba's side
The Dutchman has not played for two months since pulling a muscle in the warm-up ahead of the clash with Cagliari, but the Nerazzurri have been on a good run in that time and coach Claudio Ranieri has decided to return to the front two which has led the side for much of the fightback.
With Diego Forlan out injured after picking up a knock in training, Milito returns to the first XI having come on to score in the 4-1 win over Lecce which closed 2011.
Both Sneijder and Forlan are expected to return for the Milan derby next Sunday, but they will have to sit and watch tonight as their side take on a Parma outfit for whom Sebastian Giovinco will start just behind striker Sergio Floccari.
The clash between fifth-placed Inter and Parma, who sit 13th, kicks off at 20.45CET.
Inter (4-4-2): Julio Cesar; Maicon, Lucio, Samuel, Nagatomo; Zanetti, Thiago Motta, Cambiasso, Alvarez; Pazzini, Milito.
Subs: Castellazzi, Ranocchia, Poli, Zarate, Coutinho, Castaignos, Faraoni.
Parma (4-4-1-1): Mirante; Zaccardo, Paletta, Brandao, Gobbi; Biabiany, Morrone, Galloppa, Modesto; Giovinco; Floccari.
Subs: Pavarini, Pereira, Palladino, Musacci, Santacroce, Valiani, Pelle.