The Italy Under-21 international features in Claudio Ranieri's starting XI for the Serie A fixture, while Diego Forlan sits on the bench after returning from injury
The 22-year-old, who is on loan at the club from Sampdoria, will replace Ricky Alvarez in the midfield as the Argentine will sit on the bench.
Javier Zanetti will replace the injured Maicon on the right side of the defence, while Diego Forlan is in line to make his return after a two-month absence as he starts the match as a substitute.
As for Genoa, Alberto Malesani has opted for a 4-4-1-1 system, with Ze Eduardo the lonely striker and Alexander Merkel playing behind the Brazilian.
Genoa (4-4-1-1): Frey; Dainelli, Granqvist, Kaladze, Moretti; Mesto, Rossi, Veloso, Constant, Markel; Ze Eduardo
Subs: Lupatelli, Pratto, Jankovic, Seymour, Jorquera, Marchiori, Caracciolo
Inter (4-4-2): Julio Cesar; Zanetti, Lucio, Samuel, Nagatomo; Faraoni, Motta, Cambiasso, Poli; Milito, Pazzini.
Subs: Castellazzi, Cordoba, Forlan, Alvarez, Obi, Zarate, Muntari