The two out-of-form front men have been given a vote of confidence by coach Claudio Ranieri, while the Brazilian defensive pair return
Both strikers have been misfiring so far this term, with Pazzini now having failed to find the net in the last 11 weeks, but coach Claudio Ranieri has given the nod for the pair to head a 4-4-2 for this Saturday's game.
Brazilian defenders Maicon and Lucio return to the side after injury, but captain Javier Zanetti misses out through suspension.
Fiorentina boss Delio Rossi will send his side out in a 4-4-1-1 shape, with Adem Ljajic playing in the hole behind Italy striker Alberto Gilardino in the absence of Montenegro star Stevan Jovetic.
The clash gets underway at 20.45CET at San Siro.
Inter (4-4-2): Julio Cesar; Maicon, Lucio, Samuel, Nagatomo; Faraoni, Thiago Motta, Cambiasso, Coutinho; Pazzini, Milito.
Subs: Castellazzi, Cordoba, Alvarez, Poli, Zarate, Castaignos, Muntari.
Fiorentina (4-4-1-2): Boruc; De Silvestri, Gamberini, Natali, Pasqual; Behrami, Munari, Lazzari, Vargas; Ljajic; Gilardino.
Subs: Neto, Silva, Kharja, Nastasic, Salifu, Romizi, Romulo.