The former striker has spoken of his affection for the fixture and how he believes Delio Rossi is the right man to take charge of the Florence club
The 47-year-old represented both teams in a career spanning 14 years before a coaching career was cut short when in 2008, he was diagnosed with amyotrophic lateral sclerosis, a form of motor neuron disease which slowly forces immobility and slowly paralyses muscles.
The two teams meet at Stadio Artemio Franchi on Saturday evening and Borgonovo has spoken about the fixture.
"For me, Fiorentina - Milan always was a special challenge. I have so many memories of this game and I proudly captained Fiorentina in one of these games at San Siro," he told Tuttomercatoweb.
"If Fiorentina play at a high pace tonight, they can make it difficult for AC Milan."
Borgonovo then spoke of the recent dismissal of Sinisa Mihajlovic and the appointment of Delio Rossi.
"I'm sorry for Sinisa, I think he's a great coach but he did not find chemistry with the fans. Fiorentina now have Delio Rossi who is a great coach who fits in at Florence," he added.
"I am confident for the game [on Saturday] and for the rest of the season. I embrace all of the supporters with affection."
In October 2007, a friendly between the two sides was organised in Florence which saw a number of stars from both teams turn up to raise awareness of the rare illness, which also killed former Genoa player Gianluca Signorini in 2002.