The German attacker has fully recovered from a knee injury and will partner Djibril Cisse at the head of the attack against the capital city rivals
The Germany veteran had been in doubt for the game after picking up a knee ligament injury while away on international duty, but has been passed fit for the clash. Regarding their opponents, Francesco Totti had previously been ruled out of the clash for Luis Enrique's side.
Here are the line-ups for the game at Stadio Olimpico:
Lazio line-up (4-3-1-2): Marchetti; Konko, Dias, Biava, Radu; A.Gonzalez, Ledesma, Brocchi; Hernanes; Klose, Cisse.
Subs: Bizzarri, Lulic, Stankevicius, Cana, Matuzalem, Mauri, Rocchi
Roma line-up (4-3-1-2): Stekelenburg; Rosi, Heinze, Kjaer, Jose Angel; De Rossi, Gago, Perrotta, Pjanic; Osvaldo, Bojan
Subs: Curci, Burdisso, Cicinho, Juan, Simplicio, Borriello, Borini
Kick-off is at 2045 (CET).