The full-back makes his long-awaited comeback for Claudio Ranieri's men after successfully bouncing back from a knee injury, while the visitors' Macedonian star returns to San Siro
The Brazil defender has not appeared for the Coppa Italia holders this season due to an ongoing knee complaint, but after successful surgery and rehabilitation, he looks to have overcome his woes and will replace Yuto Nagatomo at right-back for the hosts.
Other changes also see Diego Milito dropped in favour of his South American compatriot Diego Forlan, who will partner Giampaolo Pazzini in attack.
Meanwhile, Pandev's inclusion is a result of a setback to Cavani, who picked up a knock during their 2-0 win in the Champions League to Villarreal midweek.
The blow has forced Walter Mazzarri's hand, as Ezequiel Lavezzi will be pushed up to lead the line, with the Macedonian forward playing on the left of the two in support.
The teams are as follows:
Inter (4-3-1-2): Julio Cesar, Maicon, Lucio, Samuel, Chivu; Zanetti, Cambiasso, Obi; Alvarez; Pazzini, Forlan.
Subs: Castellazzi, Nagatomo, Muntari, Stankovic, Coutinho, Castaignos, Zarate.
Napoli (3-4-2-1): De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Inler, Gargano, Zuniga; Hamsik, Pandev; Lavezzi.
Subs: Rosati, Grava, Fernandez, Fideleff, Dossena, Santana, Mascara.