The former Roma tactician will line his side up in a 4-4-2 formation against Bologna, with Giampaolo Pazzini and Walter Samuel two of the players to come into the team
Giampaolo Pazzini starts up front alongside Diego Forlan with Diego Milito and Luc Castaignos both dropping to the bench.
Andrea Ranocchia has been dropped as Walter Samuel returns to the centre of defence alongside Lucio, with Cristian Chivu and Yuto Nagatomo in the full-back positions.
Phillippe Coutinho and Joel Obi will play in midfield as Wesley Sneijder misses out with a muscle strain.
Inter will be looking for their first win of the season after only picking up one point in their opening three Serie A games.
Bologna (4-4-2): Gillet; Casarini, Portanova, Antonsson, Morleo; Perez, Mudingayi, Kone, Ramirez; Diamanti, Di Vaio
Subs: Agliardi, Krhin, Pulzetti, Vitale, Paponi, Loria, Acquafresca
Inter (4-4-2): Julio Cesar; Nagatomo, Lucio, Samuel, Coutinho, Zanetti, Cambiasso, Obi; Forlan, Pazzini
Subs: Castellazzi, Alvarez, Milito, Castaignos, Muntari, Jonathan