The Dutchman's apparent incompatibility with Gian Piero Gasperini's 3-4-3 system has resulted in his exclusion at the Renzo Barbera, with Mauro Zarate and Diego Forlan starting
The Dutch attacker will sit it out as Gian Piero Gasperini leads his side for the first time, with Jonathan, Diego Forlan and Mauro Zarate all being given debuts in a starting XI comprising no Italians.
The home side include six new signings Alexandros Tzorvas, Matias Silvestre, Eros Pisano, Edgar Alvarez, Francesco Della Rocca and Edgar Barreto as Devis Mangia takes charge on the bench with Stefano Pioli having being fired without once sending his team into league battle.
Kick-off at the Renzo Barbera is at 20:45 (CET).
Palermo (4-4-2): Tzorvas; Pisano, Silvestre, Migliaccio, Balzaretti; E. Alvarez, Barreto, Della Rocca, Ilicic; Hernandez, Miccoli.
Subs: Benussi, Mantovani, Cetto, Bertolo, Zahavi, Acquah, Pinilla.
Inter (3-4-3): Julio Cesar; Lucio, Samuel, Zanetti; Jonathan, Stankovic, Cambiasso, Nagatomo; Forlan, Milito, Zarate.
Subs: Orlandoni, Pazzini, Sneijder, R. Alvarez, Obi, Ranocchia, Castaignos.