Roma are set to start their 2011-12 campaign with a Europa League play-off fixture against Slovan Bratislava on Thursday, but will be without captain Francesco Totti and Simone Perrotta for the match.
The veteran duo are struggling with injuries and will not be available for selection for the first leg in Slovakia.
Totti is sidelined with a muscle problem and will not be risked, whilst Perrotta will travel with the squad but is not fit enough to feature, according to Il Corriere dello Sport.
New signing Erik Lamela is not yet ready as he returns from the Under-20 World Cup and Juan, David Pizarro and Leandro Greco are also not available due to injury.
On a positive note, Bojan Krkic, Jose Angel and Maarten Stekelenburg should make their competitive debuts for Luis Enrique's side.